Guanidine hydrochloride (CAS 50-01-1) is a strong protein denaturant. About 6 mol/L is a common working concentration for unfolding and inclusion-body solubilization. Guanidine isothiocyanate (CAS 593-84-0) is also a strong chaotrope. The guanidinium cation denatures proteins, including nucleases. The thiocyanate anion makes it a stronger chaotrope than the hydrochloride, which is why nucleic-acid protocols more often specify it. Catch-Chem quotes both as solids; grade follows the batch COA.
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The extraction page also lines up DTT, SDS and Proteinase K, which can be inquired together.
Related questions
Does thiocyanate by itself inhibit nucleases?
The guanidinium cation denatures proteins, including nucleases. Thiocyanate is what makes GITC the stronger chaotrope.
Can the two salts replace each other?
No. The CAS numbers and uses differ.
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Send an inquiryFor research or industrial use only. Not for human or animal diagnosis or treatment, and not for drug or food use. Grade, pack size and lead time follow the supplier batch COA / SDS. Figures on this site are general industry references, not a factory specification.